Table 4.
Ejection force (N) and QC parameters of the tablet formulations containing various tested lubricants.
| # | Lubricant * (%) |
PCF (kN) | MCF (kN) | Ejection Force (N) | Weight (mg) | Hardness (N) | Friability (%) | DT (s) |
|---|---|---|---|---|---|---|---|---|
| F-1 | Control | 0.4 | 4.3 | 349.67 ± 27.72 a | 302.4 ± 0.6 | 72.7 ± 3.4 b | >10 | 38.55 |
| F-2 | MGS 0.5% | 0.4 | 4.7 | 58.16 ± 5.54 i | 303.1 ± 0.8 | 56.3 ± 5.6 e | 0.16 | 55.13 |
| F-2 | HVO 0.5% | 0.4 | 5.1 | 83.11 ± 5.22 e | 300.6 ± 1.0 | 85.0 ± 4.0 a | 0.13 | 38.75 |
| F-4 | sFFRB 0.5% | 0.4 | 5.1 | 259.40 ± 16.56 b | 302.6 ± 1.0 | 60.3 ± 9.1 d | 1.72 | 36.28 |
| F-5 | sFFRB 1.0% | 0.4 | 4.6 | 88.17 ± 5.80 d | 302.4 ± 1.1 | 44.7 ± 4.8 f | 4.26 | 29.02 |
| F-6 | sFFRB 2.0% | 0.4 | 5.0 | 78.60 ± 5.88 f | 300.2 ± 0.6 | 27.1 ± 6.5 g | 6.89 | 27.22 |
| F-7 | sDFRB 0.5% | 0.4 | 4.5 | 89.88 ± 5.43 c | 300.1 ± 0.7 | 71.1 ± 5.8 b | 0.46 | 43.56 |
| F-8 | sDFRB 1.0% | 0.4 | 4.9 | 78.92 ± 4.66 f | 299.5 ± 0.8 | 66.2 ± 6.5 c | 0.89 | 42.05 |
| F-9 | sDFRB 2.0% | 0.4 | 4.3 | 71.88 ± 1.20 g | 299.7 ± 0.9 | 65.8 ± 4.7 c | 1.44 | 35.36 |
| F-10 | RBW 0.5% | 0.4 | 4.4 | 65.08 ± 3.32 h | 300.3 ± 1.1 | 74.7 ± 7.2 b | 0.39 | 41.60 |
* Control: no lubricant; MGS: magnesium stearate; HVO: hydrogenated vegetable oil (Lubritab); sFFRB: stabilized full-fatted rice bran; sDFRB: stabilized defatted rice bran; RBW: rice bran wax; MCF: main compression force; PCF: pre-compression force; DT: disintegration time. The values are the average ± standard deviation values. In each column, the different superscripts indicate the statistical differences of the values (p < 0.05).