Table 3.
Overview of in vitro RBE studies for α-emitters. D10,20 = absorbed dose required for 10, 20% cell survival. ED50 = activity concentration required for 50% cell survival. 177Lu is included to demonstrate reported equivalence to irradiation with 137Cs.
| Author | Cell Line | Radiopharmaceutical | Reference Radiation | End Point | RBE |
|---|---|---|---|---|---|
| Chan [64] | CA20948 (rat pancreatic) | [213Bi]Bi-DTPA | 137Cs | D10 | 2.0 |
| [213Bi]Bi-DOTATATE | 137Cs | D10 | 1.5 | ||
| [213Bi]Bi-DOTATATE | [177Lu]Lu-DOTATATE | D10 | 5.4 | ||
| [213Bi]Bi-DOTATATE | [177Lu]Lu-DOTATATE | D10 | 5.7 | ||
| BON (human carcinoid) | [213Bi]Bi-DTPA | 137Cs | D10 | 1.8 | |
| [213Bi]Bi-DOTATATE | 137Cs | D10 | 1.7 | ||
| Graf [67] | AR42J (rat pancreatic) | [225Ac]Ac-DOTATOC | [177Lu]Lu-DOTATOC | ED50 (kBq/mL) | 5.5 |
| Nayak [71] | Capan-2 (human pancreatic) | [213Bi]Bi-DOTATOC | 137Cs | D20 | 3.4 |
| [177Lu]Lu-DOTATOC | 137Cs | D20 | 1.0 |