Table 6.
Summary of clinical administration regimen. Med = median. Amino acids = lysine, arginine. Diuretic = hydrochlorothiazide. Radiosensitiser = capecitabine.
| Author | Radiopharmaceutical | Activity/Cycle (MBq) | N Cycles | Interval (Weeks) | Cumulative Activity (MBq) | Co-Admin |
|---|---|---|---|---|---|---|
| Ballal [90] | [225Ac]Ac-DOTA-TATE | 0.1/kg (8/80 kg) | 1–4 | 8 | 23 (8–33) | Amino acid |
| Ballal [91] | [225Ac]Ac-DOTA-TATE | 0.1/kg (8/80 kg) | 1–10 (med = 4) | 8 | 36 (22–59) | Amino acid, radiosensitiser |
| Delpassand [92] | [212Pb]Pb-DOTAM-TATE | 1.13/kg (90/80 kg) | 1 | 8 | 84 | Amino acid |
| 1.48/kg (118/80 kg) | 1 | 8 | 112 | Amino acid | ||
| 1.92/kg (154/80 kg) | 3 | 8 | 406 | Amino acid | ||
| 2.50/kg (200/80 kg) | 4 | 8 | 791 | Amino acid | ||
| Demirci [93] | [225Ac]Ac-DOTA-TATE | 0.1–0.12/kg (8–9.6/80 kg) | 1–3 | 18 | N/A | Amino acid |
| Giesel [94] | [213Bi]Bi-DOTA-TOC | N/A | N/A | N/A | N/A | N/A |
| Kratochwil [95] | [213Bi]Bi-DOTA-TOC | 1000–10,500 | 1–5 (med = 4.5) | 8 | 45 | Amino acid |
| Kratochwil [96] | [225Ac]Ac-DOTA-TOC | 6–60 | 1–5 (med = 4.5) | 8–52 (med = 16) | 15,800 (3300–20,600) | Amino acid, diuretic |
| Yadav [97] | [225Ac]Ac-DOTA-TATE | 0.1/kg (8/80 kg) | 2–9 (med = 3) | 8 | 42.4 (15.5–86.6) | Amino acid, radiosensitiser |
| Zhang [98] | [225Ac]Ac-DOTA-TOC | N/A | N/A | N/A | N/A | N/A |