FIG. 1.

The percentage of CpG methylation in the DS region and surrounding regions in the cell line Rael. A schematic drawing of the oriP region is shown. The positions of the following four EBNA-1-binding sites in the DS region are indicated: site 1, coordinates 9104 to 9129 in the B95-8 genome; site 2, coordinates 9083 to 9108; site 3, coordinates 9049 to 9074; and site 4, coordinates 9029 to 9055. CpG sites 4A and site 11A are not present in the B95-8 genome. The y axis shows the percentage of methylation in all clones analyzed at this CpG site. The x axis shows the individual CpG sites analyzed. Three to seven clones at each site were analyzed. Open circles, unmethylated sites.