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Long-term stability of chitosan-coated zein nanoparticles containing tobramycin.
| Months | ||||
|---|---|---|---|---|
| Parameters | 1 | 2 | 3 | 4 |
| Ø (nm) | 329.1 ± 0.3 | 328.8 ± 0.8 | 331.2 ± 0.7 | 329.4 ± 1.0 |
| PDI | 0.274 ± 0.5 | 0.272 ± 0.6 | 0.288 ± 0.5 | 0.282 ± 0.3 |
| ζ (mV) | +44.3 ± 0.2 | +42.9 ± 0.1 | +43.5 ± 0.4 | +42.3 ± 1.3 |
| pH | 4.9 | 5.0 | 5.2 | 5.2 |
| Drug content (%) | 98.64 ± 0.1 | 99.01 ± 0.2 | 98.92 ± 0.5 | 98.57 ± 0.3 |
Ø: Particle size; PDI: polydispersity index; ζ: zeta potential.
