Table 5.
Papp values of TP5, TP5-niosomes, and TP5-PEG-niosomes from the apical to the basolateral side after 6 h with different treatments (Mean ± S.D., n = 6) (p < 0.01 ** to no treatment control).
| Papp Values | Formulations | ||
|---|---|---|---|
| (10−8 cm/s) | TP5 | TP5-Niosomes | TP5-PEG-Niosomes |
| No treatment | 5.39 ± 0.46 | 4.69 ± 0.52 | 4.81 ± 0.19 |
| Sodium azide | 5.90 ± 0.52 | 3.15 ± 0.41 | 2.76 ± 0.18 ** |
| Verapamil | 6.03 ± 0.51 | 4.21 ± 0.45 | 3.06 ± 0.16 ** |
| Chlorpromazine | 5.73 ± 0.63 | 4.09 ± 0.39 | 4.25 ± 0.43 |
| MK571 | 5.04 ± 0.51 | 4.32 ± 0.51 | 5.07 ± 0.34 |
| Silymarin | 4.30 ± 0.55 | 4.00 ± 0.45 | 3.18 ± 0.15 |
| EDTA | 14.22 ± 0.89 ** | 10.73 ± 0.77 ** | 9.05 ± 0.64 ** |
| Sodium taurocholate | 13.36 ± 0.52 ** | 9.43 ± 0.69 ** | 7.24 ± 0.69 ** |