Figure 1.
(a) The chemical structures of known inhibitors of KRASG12D. (b) Normalized active RAS in tumor lysates from mice bearing Panc 04.03 xenografts treated with vehicle or MRTX1133 administered IP at the doses indicated plus one dose the next day. Brackets with * indicates statistical significance versus vehicle control using one-way ANOVA (* p < 0.05). (c) Tumor growth inhibition after IP administration of MRTX1133 BID to mice bearing MRTX1133 Panc 04.03 xenografts at the doses indicated; Brackets with * indicates tumor volumes were statistically significant versus vehicle using a two-tailed Student’s t-test (* p < 0.05). (b,c) were adapted from Ref. [9].