Table 2.
The solubility of edaravone dissolved in mixtures of water and DESs comprising choline chloride and the second constituent in a 1:2 molar ratio at 298.15 K. Standard deviation values are given in parentheses.
| x*DES 1 | P2D | B3D | DEG | TEG | ||||
|---|---|---|---|---|---|---|---|---|
| xE (×104) | cE (mg/mL) | xE (×104) | cE (mg/mL) | xE (×104) | cE (mg/mL) | xE (×104) | cE (mg/mL) | |
| 0.0 2 | 1.73 (±0.01) |
1.72 (±0.01) |
1.73 (±0.01) |
1.72 (±0.01) |
1.73 (±0.01) |
1.72 (±0.01) |
1.73 (±0.01) |
1.72 (±0.01) |
| 0.1 | 50.98 (±0.45) |
34.08 (±0.32) |
70.37 (±1.40) |
44.66 (±0.84) |
181.86 (±6.36) |
108.49 (±3.61) |
251.94 (±5.21) |
136.67 (±2.81) |
| 0.2 | 140.32 (±2.37) |
71.00 (±1.19) |
173.10 (±3.15) |
81.10 (±1.32) |
502.69 (±22.14) |
210.35 (±7.66) |
607.00 (±10.63) |
217.30 (±3.64) |
| 0.3 | 270.15 (±7.15) |
108.69 (±2.67) |
350.90 (±5.04) |
127.93 (±1.52) |
969.29 (±21.54) |
305.56 (±5.60) |
1223.75 (±19.47) |
325.47 (±3.52) |
| 0.4 | 463.56 (±8.70) |
153.13 (±2.61) |
538.01 (±9.72) |
161.55 (±2.67) |
1518.63 (±23.66) |
384.60 (±4.36) |
1852.86 (±13.62) |
398.73 (±2.73) |
| 0.5 | 694.74 (±26.13) |
195.31 (±6.52) |
831.86 (±8.04) |
209.27 (±1.69) |
1983.79 (±41.52) |
431.02 (±7.05) |
2388.18 (±23.29) |
444.40 (±4.09) |
| 0.6 | 904.23 (±9.14) |
222.13 (±1.86) |
1044.48 (±23.52) |
229.98 (±4.43) |
2189.62 (±40.44) |
429.00 (±6.24) |
2635.92 (±25.61) |
447.50 (±3.27) |
| 0.7 | 863.77 (±38.78) |
195.04 (±7.79) |
1007.49 (±15.00) |
203.22 (±2.83) |
2049.69 (±42.53) |
377.45 (±6.40) |
2524.97 (±37.72) |
397.24 (±4.90) |
| 0.8 | 801.94 (±10.87) |
168.23 (±1.97) |
928.82 (±34.85) |
173.25 (±6.06) |
1911.17 (±62.54) |
331.84 (±9.52) |
2313.80 (±40.79) |
343.41 (±5.34) |
| 0.9 | 736.17 (±10.62) |
143.75 (±1.93) |
854.66 (±13.27) |
148.11 (±2.21) |
1828.09 (±51.23) |
299.48 (±7.79) |
2213.70 (±45.66) |
308.19 (±6.00) |
| 1.0 | 660.63 (±7.59) |
120.60 (±1.27) |
760.16 (±8.22) |
123.21 (±1.25) |
1786.68 (±32.15) |
274.56 (±4.47) |
2158.65 (±28.83) |
283.35 (±3.78) |
1 x*DES denotes the mole fractions of a particular DES in solute-free mixtures with water. 2 solubility of edaravone in water was obtained from a previous study [71].