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. 2024 Feb 25;17(3):295. doi: 10.3390/ph17030295
ADME absorption, distribution, metabolism, excretion
RP-HPLC reversed-phase high-performance liquid chromatography
RP-TLC reversed-phase thin layer chromatography
Rf retention factor
b Slope
φ0 chromatographic hydrophobic index
RM0 relative lipophilicity
RM isocratic retention factor
PC(RM) principal component analysis considering RM at different isopropanol concentrations
Log P n-octanol/water partition coefficient
Log D distribution coefficient
Log S Solubility
TPSA topological polar surface area
POM Petra/Osiris/Molinspiration
GPCRs G protein-coupled receptors
HIA human intestinal absorption
BBB blood-brain barrier
P-gp P-glycoprotein
DS drug score
DL drug-likeness
r correlation coefficient
r2 the coefficient of determination
COX-2 cyclooxigenase-2