Table 1.

Summary of GWAS datasets used for LPH levels and CRC.

LPH GWAS					CRC GWAS						Colon Cancer GWAS		Rectal Cancer GWAS
Study	First Author (Year)	Sample Size	Population	Sex	Study	N Cases	N Controls	Population	Sex	CRC Ascertainment	N Cases	N Controls	N Cases	N Controls
Fenland Study	Pietzner (2021) [44]	10,708	100% European	53% Female	FinnGen Study	6509	287,137	100% European	42% Female	ICD10: C18–C20	3935	287,137	2361	287,137
					PLCO Atlas	2065	67,500	100% European	45% Female	ICD-O-2 Site: 180/182–189/199/209/212/218	1611	65,142	320	65,142
					Pan-UK Biobank	592	419,881	100% European	44% Female	Self-reported diagnosis of large bowel cancer/colorectal caner	1384	419,089	301	420,172

Abbreviations: GWAS: genome-wide association studies; LPH: lactase-phlorizin hydrolase; CRC: colorectal cancer.