Table 2.
Characteristics of genetic instruments for elevated LPH levels from the GWAS identified in the GWAS Catalog.
| RSID | Position (GRCh38) | Effect Allele | Other Allele | EAF | R2 | F | Beta | SE | p-Value | Associated Gene | cis/trans Variant for LPH Levels |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs4988235 | chr2:135851076 | A | G | 0.31 | 33.28% | 5340.06 | 0.882 | 0.011 | 3 × 10−1451 | MCM6 | cis |
| rs516246 | chr19:48702915 | C | T | 0.49 | 0.81% | 87.01 | 0.127 | 0.013 | 2 × 10−22 | FUT2 | trans |
| rs532436 | chr9:133274414 | G | A | 0.20 | 1.27% | 137.41 | 0.199 | 0.016 | 3 × 10−35 | ABO | trans |
| rs641476 | chr18:32225445 | C | T | 0.61 | 1.07% | 115.85 | 0.150 | 0.013 | 5 × 10−30 | GAREM1 | trans |
Abbreviations: LPH, lactase-phlorizin hydrolase; GWAS: genome-wide association studies; EAF: effect allele frequency; SE: standard error.