Table 1.
Clinical Scenario | ART History |
Viral Load Prior to DTG |
DTG-Containing ART |
Clinical Trials (Number Trials) |
Clinical Trials (Number PLWH) |
Cohort Studies (Number Studies) |
Cohort Studies (Number PLWH) |
Cross-Sectional Studies (Number Studies) |
Cross-Sectional Studies (Number PLWH) |
---|---|---|---|---|---|---|---|---|---|
1 | Naïve | Viremic | DTG + 2 NRTIs | 16 | 4585 | 7 | 2698 | 1 | 113 |
2 | Naïve | Viremic | DTG + 3TC | 4 | 1075 | 3 | 581 | 0 | 0 |
3 | Experienced | Viremic | DTG + 2 NRTIs | 6 | 1428 | 5 | 3630 | 4 | 218 |
4 | Experienced | Suppressed | DTG + 2 NRTIs | 3 | 877 | 3 | 2204 | 0 | 0 |
5 | Experienced | Suppressed | DTG + 2nd ARV | 10 | 1894 | 18 | 5930 | 0 | 0 |
6 | Experienced | Suppressed | DTG monotherapy | 4 | 276 | 3 | 123 | 0 | 0 |
Abbreviations: ARV—antiretroviral; ART—antiretroviral therapy; DTG—dolutegravir; PLWH—people living with HIV.