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Time course of RBD-specific IgG1 responses in immunized mice. (a) RBD-hu-1- and (b) RBD-Omicron-specific IgG1 responses are shown in serum samples from mice (1:500 dilution), immunized with 20 µg (circles) or 40 µg (triangles) of PreS-RBD fusion protein vaccines at indicated time points (x-axes). OD405/492 nm values corresponding to IgG1 antibody levels are shown (y-axes). Horizontal bars represent median values for each group.
