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IgG2a levels specific for (a) RBD-hu-1 and (b) RBD-Omicron measured in 1:500 diluted serum samples of mice immunized with 20 µg (circles) or 40 µg (triangles) of the W-PreS-O vaccine at indicated time-points (x-axes). OD405/492nm values corresponding to specific antibody levels (y-axes) are shown as the average of duplicate determinations for individual animals (n = 6 per group) with <5% deviation. Horizontal bars represent median antibody levels for each group.
