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Potential targets for TGF-β inhibition. Different levels of inhibiting TGF-β-induced fibrosis with some examples of therapeutic strategies, including the inhibition of activation of latent TGF-β by integrins or proteases, the direct blockade of TGF-β by neutralizing antibodies and soluble TβRII, inhibitors of ALK (also termed TβRI), and the inhibition of signaling pathways. Figure created by Vistnes.
