PRRSV-specific antibodies at 41 days post-infection originating from routinely PRRSV vaccinated, seropositive sows (E+ piglets; left) or piglets originating from routinely PRRSV vaccinated, seronegative/slightly seropositive sows (E− piglets; right)). Piglets were either vaccinated or non-vaccinated (NoVac) at 3 weeks of age with the same PRRSV-1 MLV as used in the sows, and all piglets were intranasally challenged with the PRRSV-1 07V063 strain at 6 weeks of age. Subgroups were made in the vaccinated piglets, based on the vaccine antibody response at 3 weeks post-vaccination, with responders having a vaccine antibody response and non-responders lacking a vaccine antibody response. The mean S/p value ± standard error of the mean is shown as error bars for each experimental group. A dotted line represents the cut-off value for seropositivity.