Table 1.
Baseline demographic, clinical, laboratory, echocardiographic and central hemodynamic characteristics of the ESCAPE study population.
| Mean ± SD or n (%) | |
|---|---|
| Age (years) | 56.13 ± 13.92 |
| Male sex | 321 (74.1%) |
| White race | 258 (59.6%) |
| Black race | 119 (27.5%) |
| BMI (Kg/m2) | 29.01 ± 6.79 |
| NYHA class IV | 368 (85.6%) |
| Rales | 225 (52.3%) |
| JVD > 12 cm | 225 (53.7%) |
| S3 gallop | 283 (65.8%) |
| HJR | 333 (79.9%) |
| LE edema at least 2+ | 155 (36%) |
| Hepatomegaly | 249 (58.2%) |
| Laboratory values | |
| BNP (pg/mL) | 1006 ± 1314 |
| BUN (mg/dL) | 34.89 ± 22.67 |
| Creatinine (mg/dL) | 1.51 ± 0.62 |
| Total bilirubin (mg/dL) | 0.86 ± 0.53 |
| Na (meq/L) | 136.66 ± 4.44 |
| Hb (gm/dL) | 12.69 ± 3.82 |
| Echocardiography | |
| EF (%) | 20.02 ± 9.55 |
| LVEDD (cm) | 6.63 ± 1.1 |
| LVESD (cm) | 5.88 ± 1.15 |
| IVC inspiration (cm) | 1.59 ± 0.72 |
| IVC expiration (cm) | 2.19 ± 0.62 |
| IVC Collapsibility index (%) | 30.11 ± 20.75 |
| PAC variables | |
| RAP (mmHg) | 12.97 ± 7.08 |
| PCWP (mmHg) | 24.72 ± 9.16 |
| COP (L/min, m ± SD) | 3.94 ± 1.37 |
| CI (L/min/m2, m ± SD) | 2 ± 0.62 |
| 6MWT | |
| Baseline 6MWD (feet) | 597 ± 374 |
| Improvement in 6MWD (feet) | 205 ± 160 |
| CPET | |
| Peak VO2 (mL/kg/min) | 10.05 ± 3.39 |
| VE max (L/min) | 41.98 ± 14.69 |
| VE/VCO2 | 41.42 ± 39.17 |
BMI: body mass index, NYHA: New York Heart Association, JVD: jugular venous distension, HJR: hepatojugular reflux, LE: lower extremity, 6MWD: 6-minute walk distance, BNP: B-type natriuretic peptide, EF: ejection fraction, LVEDD: left ventricular end-diastolic dimension, LVESD: left ventricular end-systolic dimension, IVC: inferior vena cava, RAP: right atrial pressure, PCWP: pulmonary capillary wedge pressure, COP: cardiac output, CI: cardiac index.