Figure 8.

Toxicity and efficacy of RdU in vivo. (a) H&E staining of the heart, liver, spleen, lung, kidney, and brain from the mouse used in the toxicity analysis. The control group (PBS), light groups (650 nm LED light exposed for 5 min every 2 days), RdU groups (10 mg/kg for every 2 days), and RdU + light groups (10 mg/kg drug on even days and 650 nm LED light exposed for 5 min on odd days), n = 4 per group, magnification (40×). H&E staining (b), TUNEL apoptosis assay (c), and SLC7A11 expression analysis (d) in tumor tissue. (e) The intensity of TUNEL and (f) SLC7A11 changed with different treatments.