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Putative HCF-binding domains and mutants. The amino acid sequence alignment shows that Luman and the Drosophila protein dCREB-A share, with the herpesvirus αTIF proteins, a motif that has been implicated in HCF binding in VP16 (HSV-αTIF). In this consensus (D/E)HXY(S/A) motif, we mutated amino acids D78, H79, and Y81 of Luman and amino acids E64, H65, and Y67 of dCREB-A. BHV, bovine herpesvirus.
