Figure 3.

In vivo bioimaging of PSFG micelles after intravenous injection in in situ lung cancer-bearing mice. (A) Real-time biodistribution images were taken at predominant time points after post-PSFG administration. Black dashed circles are located at the tumor site. (B) Quantitative analysis of the in vivo fluorescence intensity of tumor sites circled on the left. (C) Ex vivo fluorescence images of the major organs and tumors 48 h postinjection of PSFG. (D) The quantitative analysis of fluorescence intensity in tumors or organs, with representative images and results expressed as the mean ± SD (n = 3 mice per group). (E) Photograph and (F) H&E staining of the lungs. The green dotted line indicates the tumor area. (G) In vivo¹⁹F MRI of an orthotopic lung cancer mouse model after drip irrigation of PSFG micelles (50 μL, 10 mg mL^–1, normal saline). The content of the target product (FCy7) was detected at −59.7 ppm.