FIG. 8.

Sensitivity to menadione-induced cell death. The HVS-transformed T-cell clones ES-BP8T and SS-BP8T, their native parental clones, and Jurkat cells were cultured in the presence of different concentrations of menadione, and after 48 h PI uptake was measured and the specific cell death was determined. The native T-cell clones were treated 6 or 20 days after their last restimulation. Since no difference in the sensitivity to menadione was detected at these time points after restimulation, the results of the 10 experiments with the native T-cell clones were combined (triangles). The results of four experiments per cell line with the two transformed T-cell clones (squares) and the Jurkat cells (circles) were also combined, and the mean values (± SEM) are shown.