Figure 3.

An example: Meta Analysis with all eligible trials included. Cochrane investigators [5] were only able to pool two studies to evaluate the effect of Epo on change in hemoglobin in the patients with the baseline level of hemoglobin >12 g/dl who underwent chemotherapy. Their results show that on average Epo increases hemoglobin by 2.05 g/dl. Using our estimation formulas, we were able to include two other studies eligible for this meta-analysis ([9, 10]). The pooled estimate decreased to 1.22 g/dl, i.e., a decrease of approximately 40%.