Table 2.

Univariate and multivariate analysis of the factors associated with OS

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	$P$-value	HR (95% CI)	$P$-value
Age (year)	0.98 (0.97, 1.00)	0.021	0.98 (0.97–1.00)	0.033
Gender
Female	1
Male	1.66 (1.02, 2.68)	0.041	1.66 (1.02–2.71)	0.043
ALT (IU/L)	1.00 (1.00, 1.00)	0.704
AST (IU/L)	1.00 (1.00, 1.00)	0.957
TBIL ($\mu$mol/L)	1.00 (0.99, 1.01)	0.935
PT (s)	1.06 (0.91, 1.23)	0.461
HBV-DNA
No	1
Yes	1.19 (0.85, 1.65)	0.305	0.89 (0.63–1.26)	0.512
Tumor diameter (cm)	1.13 (1.09, 1.18)	0.001	1.09 (1.04–1.14)	0.001
Tumor number
1	1
Multiple	1.62 (1.05, 2.51)	0.03	1.62 (1.04–2.54)	0.033
Differentiation
Low	1
Middle	0.86 (0.51, 1.45)	0.572
High	0.48 (0.22, 1.05)	0.068
PVTT
No	1
Yes	2.39 (1.52, 3.75)	0.001	1.12 (0.66–1.89)	0.677
MVI
No	1
Yes	2.62 (1.88, 3.66)	0.001	1.98 (1.38–2.84)	0.001
Paracancerous tissue infiltration
No	1
Yes	0.92 (0.57, 1.48)	0.731
Invasion of liver capsule
No	1
Yes	1.34 (0.93, 1.92)	0.119
Cirrhosis
No	1
Yes	0.93 (0.65, 1.34)	0.705	0.90 (0.62–1.32)	0.601
Child-Pugh
A	1
B	1.78 (1.02, 3.11)	0.043	1.15 (0.64–2.05)	0.639
BCLC
0-A	1
B	1.09 (0.44, 2.70)	0.856
C	1.43 (1.02, 2.03)	0.041
D	0.82 (0.11, 5.90)	0.841
AAPR group
$⩽$ 0.52	1		1
$>$ 0.52	0.55 (0.38, 0.80)	0.002	0.66 (0.45–0.97)	0.036

OS: overall survival; HR: Hazard ratio; AAPR: albumin-alkaline phosphatase ratio; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBIL: total bilirubin; HGB: hemoglobin; PT: prothrombin time; HBV: hepatitis B virus; PVTT: portal vein tumor thrombus; MVI: microvascular infiltration; BCLC: Barcelona Clinic Liver Cancer.