. 2024 Jan 5;39(1):15–26. doi: 10.3233/CBM-230108

Table 4.

Subgroup analysis of prognostic factors

Subgroup	OS		RFS
	HR (95% CI)	$P$ -value	HR (95% CI)	$P$ -value
Age (year)
$<$ 60	0.63 (0.41, 0.95)	0.026	0.65 (0.49, 0.87)	0.004
$\geqslant$ 60	0.28 (0.11, 0.71)	0.008	0.37 (0.21, 0.65)	$<$ 0.001
Gender
Female	0.41 (0.14, 1.23)	0.112	0.99 (0.55, 1.81)	0.983
Male	0.57 (0.39, 0.85)	0.005	0.52 (0.39, 0.69)	$<$ 0.001
HBV-DNA
No	0.43 (0.26, 0.71)	$<$ 0.001	0.52 (0.37, 0.73)	$<$ 0.001
Yes	0.81 (0.46, 1.42)	0.466	0.74 (0.50, 1.10)	0.133
Tumor diameter (cm)
$\leqslant$ 5	0.65 (0.37, 1.14)	0.135	0.76 (0.53, 1.09)	0.131
$\geqslant$ 5	0.59 (0.35, 0.99)	0.044	0.53 (0.36, 0.78)	0.001
Tumor number
1	0.56 (0.38, 0.83)	0.004	0.61 (0.47, 0.81)	$<$ 0.001
Multiple	0.62 (0.23, 1.69)	0.352	0.51 (0.25, 1.05)	0.066
PVTT
No	0.57 (0.39, 0.85)	0.006	0.61 (0.47, 0.80)	$<$ 0.001
Yes	0.58 (0.17, 1.97)	0.384	0.59 (0.25, 1.43)	0.243
MVI
No	0.55 (0.32, 0.94)	0.027	0.63 (0.44, 0.89)	0.01
Yes	0.66 (0.40, 1.12)	0.121	0.63 (0.43, 0.93)	0.019
Cirrhosis
No	0.51 (0.33, 0.78)	0.002	0.55 (0.40, 0.75)	$<$ 0.001
Yes	0.68 (0.33, 1.38)	0.28	0.67 (0.42, 1.07)	0.096
Child-Pugh
A	0.58 (0.40, 0.84)	0.004	0.56 (0.43, 0.73)	$<$ 0.001
B	0.50 (0.07, 3.88)	0.508	3.04 (1.14, 8.15)	0.027

The AAPR $\leqslant$ 0.52 group was reference group. OS: overall survival; RFS: recurrence-free survival; HR: Hazard ratio; AAPR: albumin-alkaline phosphatase ratio; HBV: hepatitis B virus; PVTT: portal vein tumor thrombus; MVI: microvascular infiltration.