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. 2023 Nov 20;38(3):287–300. doi: 10.3233/CBM-220044

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© 2023 – The authors. Published by IOS Press.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — SFRP2 induces epithelial mesenchymal transformation and collagen production in fibroblasts. (A) Human skin and mouse pancreatic fibroblasts were either untreated (control) or treated for 48 hours with SFRP2 (30 nM) or TGF $\beta$ (5 nM), and protein levels were analyzed by western blot. Band densities (average intensity x band surface) were normalized to the loading control, GAPDH, to eliminate inter-sample variability. Results were normalized to the untreated control and presented as intensity ratio. (A, B) TGF $\beta$ and SFRP2 treatments induce an increase of N-cadherin (A) and fibronectin (B) protein levels in both human skin and mouse pancreatic fibroblasts.