Table 3.

Recent advances and emerging trends in thyroid storm diagnosis.

Diagnostic advancement	Key features	Potential impact	Current status	Future implications
Inflammatory markers (CRP, IL-6)	Elevated levels associated with thyroid storm inflammation	Enhanced accuracy in diagnosis	Explored in research, potential integration into criteria	Promising for precision
Machine learning and AI	Analyzing diverse patient data for early diagnosis	Improved early diagnosis, pattern recognition	Gaining recognition, ongoing development	Potential transformative role
NGS	Comprehensive genetic analysis	Identifying genetic variants linked to thyroid disorders	Under exploration for thyroid storm	Personalized risk assessment
Metabolomics	Studying metabolic profiles associated with thyroid storms	Insights into condition and diagnosis	Investigational, potential future application	Understanding metabolic signatures
Advanced imaging (PET, MRI)	Visualizing thyroid gland activity and inflammation	Complementing traditional criteria	Explored for diagnostic use	Valuable insights into thyroid storm pathophysiology

The table presents a comprehensive overview of recent advances and emerging trends in thyroid storm diagnosis. Each diagnostic advancement is outlined with crucial features, potential impact, current status, and future implications. From exploring of inflammatory markers like CRP and IL-6 to the promising role of machine learning and AI in early diagnosis, the table encapsulates the evolving landscape of diagnostic methodologies. Whether it is the potential precision offered by NGS or the valuable insights from studying metabolic profiles through Metabolomics, each advancement brings unique contributions to refining thyroid storm diagnosis. Including advanced imaging techniques such as PET and MRI further highlights their complementary role in traditional diagnostic criteria. This comprehensive overview serves as a guide to understanding the ongoing transformation in thyroid storm diagnosis, providing insights into the potential future directions of these diagnostic tools.

AI = artificial intelligence; CRP = C-reactive protein, IL-6 = interleukin-6; NGS = next-generation sequencing.