Table 2.
The association between albumin (g/dL) and bone alkaline phosphatase (IU/L).
| Exposure | Model 1 β (95% CI) P value | Model 2 β (95% CI) P value | Model 3 β (95% CI) P value |
|---|---|---|---|
| Albumin (g/dL) | −2.147 (−2.542, −1.751) < .001 | −2.043 (−2.448, −1.638) < .001 | −1.619 (−2.072, −1.166) < .001 |
| Gender | |||
| Male | −2.421 (−3.070, −1.772) < .001 | −2.485 (−3.151, −1.818) < .001 | −1.580 (−2.342, −0.818) .001 |
| Female | −1.854 (−2.325, −1.383) < .001 | −1.653 (−2.131, −1.176) < .001 | −1.498 (−2.025, −0.971) < .001 |
| Race/ethnicity | |||
| Non-hispanic white | −1.984 (−2.496, −1.472) < .001 | −1.948 (−2.472, −1.424) < .001 | −1.603 (−2.193, −1.013) < .001 |
| Non-hispanic black | −3.069 (−4.818, −1.320) .001 | −3.367 (−5.157, −1.577) .033 | −1.755 (−3.848, 0.338) .103 |
| Mexican American | −1.910 (−2.807, −1.013) .004 | −1.755 (−2.656, −0.854) .017 | −1.092 (−2.136, −0.047) .041 |
| Other race | −2.209 (−3.218, −1.200) .002 | −2.192 (−3.212, −1.172) .003 | −1.931 (−3.116, −0.746) .002 |
| Liver disease | |||
| Yes | −2.107 (−3.468, −0.746) .003 | −2.475 (−3.920, −1.030) .011 | −2.314 (−3.959, −0.668) .007 |
| No | −1.928 (−2.336, −1.519) < .001 | −1.794 (−2.212, −1.376) < .001 | −1.519 (−1.991, −1.047) < .001 |
| Arthritis | |||
| Yes | −2.001 (−2.464, −1.537) < .001 | −1.878 (−2.348, −1.409) < .001 | −1.582 (−2.100, −1.064) < .001 |
| No | −2.298 (−2.965, −1.631) < .001 | −2.201 (−2.890, −1.512) < .001 | −1.646 (−2.421, −0.871) .003 |
| Gout | |||
| Yes | −2.683 (−3.963, −1.404) .006 | −2.617 (−3.911, −1.323) .0011 | −0.676 (−2.061, 0.709) .341 |
| No | −2.045 (−2.462, −1.629) < .001 | −1.924 (−2.352, −1.497) < .001 | −1.613 (−2.095, −1.130) < .001 |
Model 1: no covariates were adjusted. Model 2: age, sex, and race/ethnicity were adjusted. Model 3: age, sex, race/ethnicity, alanine aminotransferase, blood urea nitrogen, creatine phosphokinase, cholesterol, creatinine, gamma glutamyl transferase, glucose, phosphorus, total protein, uric acid, globulin, triglycerides, body mass index, aspartate aminotransferase. Iron lactate dehydrogenase, arthritis, gout, liver disease were adjusted. In the subgroup analysis stratified by sex, race/ethnicity, liver disease, arthritis and gout, the model is not adjusted for the stratification variable itself.