Table 2.

Mendelian randomization estimates for the association between gut microbiota and ovarian cancer.

Bacterial taxa (exposure)	Outcome	MR method	No. SNP	P-value	OR	95%CI
Genus Victivallis	OC	IVW	9	.039	1.10	1.00–1.20
Family Streptococcaceae	OCED	IVW	12	.009	1.64	1.13–2.39
Genus Adlercreutzia	OCED	IVW	8	.004	1.53	1.15–2.04
Genus Ruminiclostridium6	OCED	IVW	16	.012	1.36	1.07–1.72
Genus Oscillibacter	OCCC	IVW	14	.021	0.70	0.52–0.95
Family Alcaligenaceae	SOC	IVW	12	.025	0.82	0.69–0.98
Genus Romboutsia	SOC	IVW	13	.031	1.17	1.01–1.34
Genus Collinsella	LGSOC	IVW	9	.029	0.52	0.29–0.93
Genus Peptococcus	LGSOC	IVW	12	.036	1.40	1.02–1.91
Phylum Cyanobacteria	LGSOC	IVW	8	.036	1.56	1.03–2.36
Family Alcaligenaceae	HGSOC	IVW	12	.019	0.81	0.68–0.97
Genus Romboutsia	HGSOC	IVW	13	.05	1.15	1.00–1.33
Genus Candidatus Soleaferrea	MOC	IVW	10	.027	0.77	0.61–0.97
Genus Lachnospiraceae NC2004 group	MOC	IVW	9	.047	0.76	0.57–1.00
Genus Olsenella	MOC	IVW	11	.049	0.81	0.65–1.00
Genus Ruminiclostridium5	MOC	IVW	11	.006	1.67	1.16–2.40
Genus Ruminococcaceae NK4A214 group	MOC	IVW	13	.045	1.39	1.01–1.91
Phylum Proteobacteria	MOC	IVW	11	.033	0.68	0.48–0.97
Phylum Bacteroidetes	LMPMOC	IVW	12	.012	1.84	1.14–2.97
Phylum Firmicutes	LMPMOC	IVW	17	.021	0.63	0.42–0.93
Phylum Lentisphaerae	LMPMOC	IVW	9	.026	1.40	1.04–1.87
Genus Candidatus Soleaferrea	IMOC	IVW	10	.03	0.71	0.53–0.97
Genus Ruminococcaceae NK4A214 group	IMOC	IVW	13	.044	1.54	1.01–2.36
Phylum Proteobacteria	IMOC	IVW	11	.022	0.58	0.36–0.92

CI = confidence interval, HGSOC = high grade serous ovarian cancer, IMOC = invasive mucinous ovarian cancer; IVW = inverse variance weighted, LGSOC = low grade serous ovarian cancer, LMPMOC = low malignant potential mucinous ovarian cancer, MR = Mendelian randomization, OC = ovarian cancer, OCCC = clear cell ovarian cancer, OCED = endometrioid ovarian cancer, OR = odds ratio, SNPs = single nucleotide polymorphisms, SOC = serous ovarian cancer.