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. 2024 Apr;30(4):721–731. doi: 10.3201/eid3004.231457

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Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

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Ct values for virus-specific nucleoprotein RNA in mice engrafted with rhesus monkey immune cells infected with diverse simarteriviruses causing hemorrhagic disease. NSG-SGM3 (NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Tg[CMV-IL3,CSF2,KITLG]1Eav/MloySzJ) mice were engrafted with fetal CD34+-enriched hematopoietic stem and progenitor cells isolated from rhesus monkeys. Engrafted and unengrafted NSG-SGM3 transgenic mice and background-matched wild-type NOR/LtJ mice were injected intraperitoneally and intravenously with 1 of 4 viruses: A) simian hemorrhagic fever virus; B) Kibale red colobus monkey virus 1; C) Pebjah virus; or D) Southwest baboon virus 1. Production of virus-specific nucleoprotein RNA in blood was measured over time by using quantitative reverse transcription PCR. Dotted lines indicates limit of detection. Ct, cycle threshold.