Fig 12. Ranking of all denoising strategies across multiple performance metrics.

We ranked strategies across four metrics from best to worst. Larger circles with brighter color represent higher ranking. Metric “correlation between network modularity and motion” has been excluded from the summary as it is potentially a poor measure. Loss of temporal degrees of freedom is a crucial measure that should be taken into account alongside the metric rankings. A clear trade-off is apparent between loss in degrees of freedom and the quality of denoising, so no overall ranking of methods is derived from this analysis—see text for a summary of key takeaways.