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. 2024 Feb 22;8(5):ziae023. doi: 10.1093/jbmrpl/ziae023

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© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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The cytokine profile within bone changes with age. Lysates of tibial diaphyses from uninjured mice were investigated for cytokine profile using multiplex ELISA. Calculated cytokine amounts were normalized to total amount of protein within the lysate. (A) IL-1β; (B) IL-9; (C) IFNγ; (D) CCL3/MIP-1α; (E) IL-2; (F) TNFα; (G) TNFR1; (H) IL-4; (I) IL-10; (J) CXCL1/KC-GRO; (K) CXCL2/MIP-2; (L) IL-6; and (M) CCL2/MCP-1 were determined from lysates of young and old, male and female mice. N = 5–6; two-tailed t-tests were conducted. ^*P < 0.05, ^*^*P < 0.01, ^*^*^*P < 0.001 (YM, young males; OM, old males; YF, young females; OF, old females).