Table 4.

The value of various combinations of lung cancer screening markers in patients with benign lung lesions.

Benign lung disease	SEN	SPE	PPV	NPV	+LR	−LR	Yden	AUC
CEA + NSE▴	0.693	0.620	0.585	0.724	1.829	0.494	0.410	0.723
CEA + GRP	0.730	0.584	0.575	0.737	1.758	0.461	0.426	0.667
GRP + NSE	0.663	0.719	0.645	0.734	2.365	0.468	0.407	0.697
CEA + GRP + NSE★	0.804	0.525	0.563	0.781	1.719	0.367	0.427	0.734