Table 8.
AUC for various combinations of markers to screen for lung cancer in different populations at different ages.
| Healthy | Benign lung disease | |||
|---|---|---|---|---|
| Year | <65 | ≥65 | <65 | ≥65 |
| CEA | 0.746 | 0.742 | 0.632 | 0.640 |
| NSE | 0.615 | 0.726 | 0.652 c1 | 0.743 d1 |
| GRP | 0.562 | 0.672 | 0.568 | 0.601 |
| CA125 | 0.694 | 0.768 | 0.542 | 0.549 |
| CEA + NSE | 0.762 a1 | 0.800 b1 | 0.697 c2 | 0.759 d2 |
| CEA + GRP | 0.785 a2 | 0.794 | 0.647 | 0.685 |
| NSE + GRP | 0.644 | 0.733 | 0.637 | 0.729 |
| CEA + CA125 | 0.785 a3 | 0.808 b2 | 0.625 | 0.644 |
| CA125 + GRP | 0.735 | 0.798 | 0.585 | 0.603 |
| CA125 + NSE | 0.721 | 0.800 b3 | 0.652 c3 | 0.743 d3 |
a1 vs a2: Z = 1.202 P=0.2293; a1 vs a3: Z = 1.445 P=0.1484 ; a2 vs a3: Z = 0.004 P=0.9964; b1 vs b2: Z = 0.256 P=0.7977; b1 vs b3: Z = 0.007 P=0.9938; b2 vs b3: Z = 0.455 P=0.6492; c1 vs c2: Z = 2.973 P=0.0029; c1 vs c3: Z = 0.076 P=0.9387; c2 vs c3: Z = 3.005 P=0.0027; d1vsd2: Z = 1.003 P=0.3160; d1 vs d3: Z = 0.097 P=0.92222; d2 vs d3: Z = 1.007 P=0.3410.