Figure 4.

Acetylation-deficient p534KR increases cardiac glucose transporters and glycolytic function. A and B, Representative immunoblots and quantitative analysis of PFK-1, GLUT-1, GLUT-4, α-tubulin, and GAPDH in the indicated groups. PFK-1 and corresponding GAPDH were from the same membrane. Glut-1 and α-tubulin were from the same membrane. Glut-4 and corresponding GAPDH were from the same membrane. C, Cardiac F2,6-BP level was determined by the coupled-enzymatic assay and expressed as the fold change to the WT sham group. n=3–4. D, Cardiac PFK-1 activity was determined by the coupled-enzymatic assay and expressed as the OD340nm/min/mg protein. n=5–9.