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. 2022 May 28;17:100148. doi: 10.1016/j.ahjo.2022.100148

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Specialized pro-resolving mediator biosynthetic pathways [65]. (A) Biosynthesis of the D series resolvins, protectins, and maresins from docosahexaenoic acid (DHA) and the E series resolvins from eicosapentaenoic acid (EPA). (B) Biosynthesis of lipoxins and aspirin-triggered (AT)-lipoxins from arachidonic acid (AA), the T series resolvins AT-RvDs and AT-PD1 from DHA, and the resolvin, protectin, and maresin conjugates in tissue regeneration (RCTRs, PCTRs, MCTRs) from their epoxy precursors. 15-LOX, 15-lipoxygenase; 5-LOX, 5-lipoxygenase; 12-LOX, 12-lipoxygenase; COX2-ASA, aspirin-acetylated cyclooxygenase-2; P450, cytochrome P450; RvD1, resolvin D1; RvD2, resolvin D2; RvD3, resolvin D3; RvD4, resolvin D4; PD1/NPD1, protectin D1/neuroprotectin D1; MaR1, maresin 1; RvE1, resolvin E1; RvE2, resolvin E2; RvE3, resolvin E3; LXA₄, lipoxin A₄; LXB₄, lipoxin B₄; AT-LXA₄, aspirin-triggered lipoxin A₄. Reprinted with permission from Panigrahy D, Gilligan MM, Serhan CN, Kashfi K. Resolution of inflammation: An organizing principle in biology and medicine. Pharmacol Ther 2021;227:107879. Copyright 2021, with permission from Elsevier.