Table 2.
Summary results of the dose setting study
| Test substance | Dose (%) | S9 mix | Trt-rec time (h) |
Relative population doubling (%) | PD |
|---|---|---|---|---|---|
| Negative control (saline) | 0 | – | 6-18 | 100 | 1.53 |
| NPP | 0.313 | – | 6-18 | 98.5 | - |
| 0.625 | – | 6-18 | 97.0 | - | |
| 1.25 | – | 6-18 | 95.5 | - | |
| 2.5 | – | 6-18 | 93.9 | - | |
| 5 | – | 6-18 | 91.8 | - | |
| 10 | – | 6-18 | 88.5 | - | |
| Negative control (saline) | 0 | + | 6-18 | 100 | 1.53 |
| NPP | 0.313 | + | 6-18 | 98.5 | - |
| 0.625 | + | 6-18 | 97.5 | - | |
| 1.25 | + | 6-18 | 95.9 | - | |
| 2.5 | + | 6-18 | 94.4 | - | |
| 5 | + | 6-18 | 90.0 | - | |
| 10 | + | 6-18 | 86.7 | - | |
| Negative control (saline) | 0 | – | 24-0 | 100 | 1.54 |
| NPP | 0.313 | – | 24-0 | 98.5 | - |
| 0.625 | – | 24-0 | 96.5 | - | |
| 1.25 | – | 24-0 | 94.5 | - | |
| 2.5 | – | 24-0 | 93.4 | - | |
| 5 | – | 24-0 | 90.2 | - | |
| 10 | – | 24-0 | 88.1 | - |
NPP, no-pain pharmacopuncture (A four-herb extract consisting of Corydalis tube, Chaenomelis Fructus, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma; Trt-rec time, treatment-recovery times).
Relative population doubling (RPD) = (no. population doubling in treated cultures) (no. population doubling in control cultures) × 100.
Population doubling (PD) = [log (post-treatment cell number/initial cell number)]/log 2.