Table 2.

CpG sites from EWAS of body mass index and gestational weight gain significant after Bonferroni correction.

CpG-site	Chromosome	Position	Location in relation to gene	β	SE	p-value	Associated gene+	Gene summary **
EWAS of body mass index, meta-analysis approach
cg02786370*	4	2,747,928	Open sea	−0.02	0.0031	2.12 × 10−10	TNIP2	NCBI gene ID 79155. Encodes a protein that inhibits NfkappaB-activation, is involved in MAP/ERK-signaling pathway in some cells, and could be involved in endothelial cell apoptosis.
Cg19758958*	11	62,319,222	Open sea	−0.01	0.0018	1.12 × 10−9	Promoter region of AHNAC	NCBI gene ID 79026. Encodes a structural scaffold protein that may play a role in blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis
cg10472537*	2	105,348,800	Open sea	−0.01	0.002	2.05 × 10−8	Unannotated
cg16444328	5	171,279,429	Open sea	−0.01	0.0015	3.76 × 10−8	Unannotated
cg24911837	7	65,227,864	North shore	−0.01	0.0024	3.96 × 10−8	CCT6P1	NCBI gene ID 643253. No summary of function available
EWAS of gestational weight gain, meta-analysis approach
cg16733643	1	41,575,522	Open sea	−0.35	0.065	5.82 × 10−8	SCMH1	NCBI gene ID 22955. Encodes a protein that is predicted to impact chromatin and histone binding activity and thereby negatively impact transcription of DNA.
EWAS of body mass index, European ancestry
cg02786370	4	2,747,928	Open sea	−0.02	0.0031	2.12 × 10−10	TNIP2	NCBI gene ID 79155. Encodes a protein that inhibits NfkappaB-activation, is involved in MAP/ERK-signaling pathway in some cells, and could be involved in endothelial cell apoptosis.
cg19877790	13	35,009,671	Open sea	−0.01	0.0034	2,09 × 10−8	LINC00457	NCBI gene ID 100874179. Non protein coding RNA.

Chr chromosome, Pos position, + From the EWAS catalog.

*Replicated in The Norwegian Mother, Father and Child Cohort Study of Assisted Reproductive Technology (MoBa-START), using body mass index at week 30, p < 0.05.

**Genome Reference Consortium Human Build 37.