Table 2.

Changes in size of fat depots.

	Size of fat depots		In-group differences		Between-group differences
	PreOP mean, cm2	3 years mean, cm2	PreOP vs. 3 years		PreOP		Change (PreOP-3 years)
	±SEM	±SEM	Δ (95% CI)	p-value	Diff. (95% CI)	p-value	Diff. (95% CI)	p-value
All patients
VAT, cm2
Left-sided	158 ± 12.76	172 ± 12.92	1.05 (1.02–1.09)	<0.01	1.02 (0.97–1.09)	0.42	1.03 (0.98–1.09)	0.24
Right-sided	145 ± 14.78	147 ± 14.99	1.02 (0.98–1.06)	0.38
SAT, cm2
Left-sided	199 ± 10.75	215 ± 10.98	1.04 (1.02–1.06)	<0.001	1.06 (1.06–1.07)	0.87	0.98 (0.95–1.01)	0.24
Right-sided	182 ± 11.10	208 ± 12.38	1.06 (1.04–1.09)	<0.001
TAT, cm2
Left-sided	353 ± 19.26	386 ± 18.80	1.05 (1.02–1.07)	<0.01	1.02 (0.98–1.06)	0.77	1.00 (0.97–1.04)	0.92
Right-sided	325 ± 20.95	354 ± 21.68	1.04 (1.01–1.07)	<0.01
V/S ratio
Left-sided	0.85 ± 0.07	0.88 ± 0.07	1.01 (0.98–1.03)	0.59	1.05 (0.93–1.18)	0.41	1.05 (1.00–1.09)	0.03
Right-sided	0.80 ± 0.09	0.75 ± 0.09	0.96 (0.93–0.99)	0.02
Men
VAT, cm2
Left-sided	206 ± 19.21	224 ± 18.89	1.06 (1.02–1.10)	<0.01	1.02 (0.94–1.11)	0.59	1.05 (0.98–1.13)	0.14
Right-sided	214 ± 25.95	212 ± 27.58	1.01 (0.95–1.06)	0.84
SAT, cm2
Left-sided	163 ± 11.62	176 ± 10.78	1.04 (1.01–1.07)	<0.01	0.99 (0.94–1.05)	0.85	0.99 (0.94–1.03)	0.52
Right-sided	152 ± 13.71	172 ± 16.47	1.06 (1.02–1.09)	<0.01
TAT, cm2
Left-sided	367 ± 29.18	398 ± 27.07	1.04 (1.01–1.08)	0.01	1.01 (0.94–1.08)	0.82	1.02 (0.96–1.07	0.66
Right-sided	366 ± 36.59	384 ± 38.80	1.03 (0.99–1.08)	0.14
V/S ratio
Left-sided	1.27 ± 0.09	1.27 ± 0.09	1.01 (0.98–1.04)	0.54	1.00 (0.89–1.13)	0.94	1.05 (1.01–1.10)	0.03
Right-sided	1.30 ± 0.15	1.21 ± 0.16	0.96 (0.93–0.99)	0.02
Women
VAT, cm2
Left-sided	110 ± 13.17	119 ± 13.3	1.04 (0.99–1.10)	0.12	1.01 (0.93–1.10)	0.81	1.02 (0.94–1.10)	0.69
Right-sided	98 ± 11.86	101 ± 11.50	1.03 (0.97–1.09)	0.37
SAT, cm2
Left-sided	234 ± 16.34	257 ± 17.12	1.05 (1.01–1.08)	<0.01	1.00 (0.96–1.05)	0.83	0.98 (0.93–1.03)	0.38
Right-sided	205 ± 15.38	236 ± 16.28	1.07 (1.03–1.11)	<0.001
TAT, cm2
Left-sided	339 ± 25.39	373 ± 26.27	1.05 (1.01–1.08)	<0.01	1.01 (0.96–1.06)	0.78	0.99 (0.94–1.05)	0.79
Right-sided	292 ± 23.48	332 ± 24.55	1.05 (1.01–1.10)	0.01
V/S ratio
Left-sided	0.45 ± 0.05	0.46 ± 0.05	1.01 (0.96–1.05)	0.79	1.00 (0.89–1.13)	0.99	1.04 (0.97–1.12)	0.27
Right-sided	0.41 ± 0.04	0.40 ± 0.04	0.97 (0.92–1.02)	0.23

Means (SEM) are based on available data (PreOp, 3 years) for patients who underwent left-sided or right-sided colonic cancer resection.

In-group and between-group differences were analyzed using a unified linear mixed effects model. Logarithmic values were used. In group and between group changes don’t reflect the numerical difference between preoperative and 3 years, given that mean change is estimated based on mixed-model analysis.

VAT Visceral adipose tissue, SAT Subcutaneous adipose tissue, TAT Total adipose tissue, V/S VAT/SAT ratio, PreOP Preoperative.