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(A) Probability of start-gain formation based on COSMIC v1 mutational signature. The red dashed line indicates the probability of start-gain formation given a neutral mutational signature. (B) Heatmap of relative composition of mutations attributable to a given mutational signature averaged within each cancer group. Proposed aetiologies for the mutational signatures include: aging (1A/B), smoking (4), DNA mismatch repair (6, 14, 15, 20, 21), POLE mutation (10,14) and UV (7) (35, 42).
