Table 2.
KSHV Gene | RFHV percent identity | RRV percent identity | MHV68 percent identity | GPHLV percent identity | KSHV gene | RFHV percent identity | RRV percent identity | MHV68 percent identity | GPHLV percent identity |
---|---|---|---|---|---|---|---|---|---|
K1a | 28.10% | ORF 40 | 43.90% | 33.20% | 26.00% | 24.20% | |||
ORF 4 | 39.90% | 44.10% | 28.50% | 33.20% | ORF 42 | 60.20% | 46.80% | 36.80% | 37.50% |
ORF6 | 71.50% | 63.20% | 40.60% | 47.50% | ORF 43 | 75.70% | 63.70% | 48.20% | 56.00% |
ORF7 | 58.90% | 52.70% | 34.30% | 39.70% | ORF 44 | 74.40% | 65.80% | 54.70% | 57.10% |
ORF8 | 71.30% | 66.70% | 53.70% | 56.50% | ORF 45 | 40.20% | 37.30% | ||
ORF9 | 75.70% | 67.10% | 56.60% | 55.30% | ORF 46 | 69.00% | 59.80% | 53.60% | 53.80% |
ORF 10 | 44.60% | 34.00% | 23.00% | 18.90% | ORF 47 | 47.70% | 29.30% | 28.90% | 29.60% |
ORF 11 | 33.80% | ORF 48 | 36.20% | 32.50% | 23.40% | 23.90% | |||
K2a | 34.50% | ORF 49 | 64.20% | 54.30% | 21.90% | 22.40% | |||
ORF2 | 57.90% | 46.50% | ORF 50 | 55.20% | 55.70% | 28.70% | |||
K3 | 41.50% | K8 | 31.80% | ||||||
ORF 70 | 74.00% | 73.80% | K8.1 | ||||||
K4 | 60.60% | 44.10% | ORF 52 | 55.00% | 46.20% | 31.50% | 38.30% | ||
K4.1 | 55.40% | ORF 53 | 71.70% | 61.50% | 37.50% | 34.50% | |||
K4.2 | ORF 54 | 50.00% | 41.80% | 32.50% | 33.80% | ||||
K5 | 39.80% | 29.70% | ORF 55 | 75.90% | 60.20% | 42.40% | 40.50% | ||
K6 | 51.10% | 37.50% | ORF 56 | 58.40% | 52.40% | 36.20% | 37.30% | ||
K7 | ORF 57 | 55.20% | 44.70% | 30.80% | |||||
ORF 16a | 42.30% | 49.70% | K9a | 40.10% | 28.40% | ||||
ORF 17 | 48.40% | 42.80% | 35.00% | 36.00% | K10 | ||||
ORF 17.5 | 34.50% | 32.20% | 29.80% | 27.70% | K10.6a | ||||
ORF 18 | 66.10% | 58.00% | 41.50% | 43.20% | K11 | 41.30% | |||
ORF 19 | 59.50% | 52.80% | 36.10% | 42.10% | ORF 58 | 52.60% | 38.70% | 21.70% | 30.40% |
ORF 20 | 51.80% | 48.00% | 34.30% | 42.30% | ORF 59 | 58.10% | 52.20% | 36.10% | 26.00% |
ORF 21 | 54.60% | 44.50% | 30.00% | 35.90% | ORF 60 | 79.70% | 69.80% | 61.30% | 63.60% |
ORF 22 | 49.90% | 40.80% | 29.40% | 32.70% | ORF 61 | 71.40% | 65.70% | 47.40% | 49.90% |
ORF 23 | 53.90% | 48.40% | 25.40% | 34.40% | ORF 62 | 65.90% | 56.50% | 28.20% | 34.00% |
ORF 24 | 66.30% | 59.20% | 41.50% | 44.20% | ORF 63 | 44.90% | 42.70% | 23.90% | 26.90% |
ORF 25 | 82.10% | 72.40% | 56.80% | 61.20% | ORF 64 | 47.60% | 38.40% | 25.80% | 27.70% |
ORF 26 | 78.30% | 65.10% | 41.90% | 45.70% | ORF 65 | 46.60% | 43.80% | 37.80% | |
ORF 27 | 44.80% | 28.90% | 27.20% | ORF 66 | 57.90% | 47.30% | 31.50% | 38.30% | |
ORF 28 | 51.00% | ORF 67 | 64.00% | 66.10% | 43.10% | 50.80% | |||
ORF 29 | 72.10% | 66.40% | 49.60% | 57.10% | ORF 67A | 60.80% | 66.70% | 43.10% | |
ORF 30 | 44.30% | 34.50% | 43.30% | ORF 68 | 60.50% | 48.00% | 33.00% | 37.90% | |
ORF 31 | 67.70% | 48.70% | 38.00% | 35.40% | ORF 69 | 68.10% | 61.70% | 46.20% | 42.30% |
ORF 32 | 44.00% | 40.60% | 24.00% | 26.00% | K12 | ||||
ORF 33 | 60.90% | 42.90% | 34.30% | 34.60% | ORF 71a | 54.90% | 33.30% | ||
ORF 34 | 60.10% | 49.20% | 30.40% | 39.20% | ORF 72a | 47.30% | 41.00% | 31.80% | 34.40% |
ORF 35 | 56.00% | 37.90% | 28.60% | 34.70% | ORF 73a | ||||
ORF 36a | 67.10% | 46.20% | 27.50% | 30.10% | K14 | 40.90% | 36.40% | ||
ORF 37 | 72.20% | 63.70% | 44.70% | 47.60% | ORF 74a | 56.70% | 44.40% | 24.80% | 26.90% |
ORF 38 | 52.40% | 47.40% | 28.60% | ORF 75 | 62.20% | 43.60% | 27.70% | 28.60% | |
ORF 39 | 66.00% | 59.50% | 51.50% | 47.40% | K15a | 24.40% |
The Proteome Comparison Tool which is available through the BACTERIAL AND VIRAL BIOINFORMATICS RESOURCE CENTER (BV-BRC) was used to compare the proteomes of viruses used in current animal models of KSHV pathogenesis: Retroperitoneal fibromatosis-associated herpesvirus (RFHV), Macacine gammaherpesvirus 5 (RRV), Murid gammaherpesvirus 4 (MHV68), and Guinea Pig Herpes Like Virus (GPHLV) were compared to human KSHV
Percent Identity is calculated relative to the homologous KSHV protein
Proteins with identities less than 0.1 and a coverage of 0.3 were excluded from the analysis
aDenotes known KSHV oncogenes