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. 2024 Feb 10;60(2):148–158. doi: 10.1007/s11262-024-02054-x

Table 2.

Proteomic comparison of RFHV, RRV, MHV68, and GPHLV to KSHV

KSHV Gene RFHV percent identity RRV percent identity MHV68 percent identity GPHLV percent identity KSHV gene RFHV percent identity RRV percent identity MHV68 percent identity GPHLV percent identity
K1a 28.10% ORF 40 43.90% 33.20% 26.00% 24.20%
ORF 4 39.90% 44.10% 28.50% 33.20% ORF 42 60.20% 46.80% 36.80% 37.50%
ORF6 71.50% 63.20% 40.60% 47.50% ORF 43 75.70% 63.70% 48.20% 56.00%
ORF7 58.90% 52.70% 34.30% 39.70% ORF 44 74.40% 65.80% 54.70% 57.10%
ORF8 71.30% 66.70% 53.70% 56.50% ORF 45 40.20% 37.30%
ORF9 75.70% 67.10% 56.60% 55.30% ORF 46 69.00% 59.80% 53.60% 53.80%
ORF 10 44.60% 34.00% 23.00% 18.90% ORF 47 47.70% 29.30% 28.90% 29.60%
ORF 11 33.80% ORF 48 36.20% 32.50% 23.40% 23.90%
K2a 34.50% ORF 49 64.20% 54.30% 21.90% 22.40%
ORF2 57.90% 46.50% ORF 50 55.20% 55.70% 28.70%
K3 41.50% K8 31.80%
ORF 70 74.00% 73.80% K8.1
K4 60.60% 44.10% ORF 52 55.00% 46.20% 31.50% 38.30%
K4.1 55.40% ORF 53 71.70% 61.50% 37.50% 34.50%
K4.2 ORF 54 50.00% 41.80% 32.50% 33.80%
K5 39.80% 29.70% ORF 55 75.90% 60.20% 42.40% 40.50%
K6 51.10% 37.50% ORF 56 58.40% 52.40% 36.20% 37.30%
K7 ORF 57 55.20% 44.70% 30.80%
ORF 16a 42.30% 49.70% K9a 40.10% 28.40%
ORF 17 48.40% 42.80% 35.00% 36.00% K10
ORF 17.5 34.50% 32.20% 29.80% 27.70% K10.6a
ORF 18 66.10% 58.00% 41.50% 43.20% K11 41.30%
ORF 19 59.50% 52.80% 36.10% 42.10% ORF 58 52.60% 38.70% 21.70% 30.40%
ORF 20 51.80% 48.00% 34.30% 42.30% ORF 59 58.10% 52.20% 36.10% 26.00%
ORF 21 54.60% 44.50% 30.00% 35.90% ORF 60 79.70% 69.80% 61.30% 63.60%
ORF 22 49.90% 40.80% 29.40% 32.70% ORF 61 71.40% 65.70% 47.40% 49.90%
ORF 23 53.90% 48.40% 25.40% 34.40% ORF 62 65.90% 56.50% 28.20% 34.00%
ORF 24 66.30% 59.20% 41.50% 44.20% ORF 63 44.90% 42.70% 23.90% 26.90%
ORF 25 82.10% 72.40% 56.80% 61.20% ORF 64 47.60% 38.40% 25.80% 27.70%
ORF 26 78.30% 65.10% 41.90% 45.70% ORF 65 46.60% 43.80% 37.80%
ORF 27 44.80% 28.90% 27.20% ORF 66 57.90% 47.30% 31.50% 38.30%
ORF 28 51.00% ORF 67 64.00% 66.10% 43.10% 50.80%
ORF 29 72.10% 66.40% 49.60% 57.10% ORF 67A 60.80% 66.70% 43.10%
ORF 30 44.30% 34.50% 43.30% ORF 68 60.50% 48.00% 33.00% 37.90%
ORF 31 67.70% 48.70% 38.00% 35.40% ORF 69 68.10% 61.70% 46.20% 42.30%
ORF 32 44.00% 40.60% 24.00% 26.00% K12
ORF 33 60.90% 42.90% 34.30% 34.60% ORF 71a 54.90% 33.30%
ORF 34 60.10% 49.20% 30.40% 39.20% ORF 72a 47.30% 41.00% 31.80% 34.40%
ORF 35 56.00% 37.90% 28.60% 34.70% ORF 73a
ORF 36a 67.10% 46.20% 27.50% 30.10% K14 40.90% 36.40%
ORF 37 72.20% 63.70% 44.70% 47.60% ORF 74a 56.70% 44.40% 24.80% 26.90%
ORF 38 52.40% 47.40% 28.60% ORF 75 62.20% 43.60% 27.70% 28.60%
ORF 39 66.00% 59.50% 51.50% 47.40% K15a 24.40%

The Proteome Comparison Tool which is available through the BACTERIAL AND VIRAL BIOINFORMATICS RESOURCE CENTER (BV-BRC) was used to compare the proteomes of viruses used in current animal models of KSHV pathogenesis: Retroperitoneal fibromatosis-associated herpesvirus (RFHV), Macacine gammaherpesvirus 5 (RRV), Murid gammaherpesvirus 4 (MHV68), and Guinea Pig Herpes Like Virus (GPHLV) were compared to human KSHV

Percent Identity is calculated relative to the homologous KSHV protein

Proteins with identities less than 0.1 and a coverage of 0.3 were excluded from the analysis

aDenotes known KSHV oncogenes