Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 15;11:1366113. doi: 10.3389/fmolb.2024.1366113

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Yang, Wei and She.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Kinesin-7 CENP-E is essential for kinetochore-microtubule attachment, chromosome alignment, and spindle assembly checkpoint in cell division. (A–C) CENP-E proteins are located at microtubules in prophase and accumulate at the kinetochores in prometaphase. CENP-E plays a key role in kinetochore-microtubule attachment and chromosome alignment during prometaphase and metaphase. (D) CENP-E ablation results in chromosome misalignment, spindle disorganization, and the activation of the spindle assembly checkpoint. (E) In wild-type cells, CENP-E proteins are essential for chromosome alignment, kinetochore-microtubule attachment, and the regulation of spindle assembly checkpoint. In the absence of CENP-E, the chromosomes are mono-oriented and misaligned, which further forms a wait anaphase signal and activates the spindle assembly checkpoint.