FIGURE 6.

Drug resistance of CENP-E inhibitors. Tumor cells can develop resistance to CENP-E inhibitors through the CENP-E gene mutation, membrane transporter proteins overexpression, or their own CENP-E expression level. For example, the deletion of DNA in KBM7 cells will lead to the deletion of the CENP-E tail domain, which in turn leads to specific resistance to GSK923295. The overexpression of P-glycoprotein (Pgp) can also lead to resistance to GSK923295, but the low expression of the Pgp gene in GSK923295-resistant KBM7 cells suggests that cells may generate different mechanisms of drug resistance. No common characteristics of 25 GSK923295-resistant cell lines indicate that other molecular pathways lead to drug resistance.