TABLE 1.
Expression patterns of CENP-E proteins in multiple cancers.
| Cancer types | Type | Level | Functions of CENP-E | Loss-of-function phenotypes | References |
|---|---|---|---|---|---|
| Ovarian cancer | Gene | + | Stimulates cell proliferation, migration, and epithelial-mesenchymal transition | Obscure | Ju et al., 2009; Li et al., 2020 |
| Prostate cancer | Protein | + | A novel biomarker and therapeutic target for the treatment of castration-resistant prostate cancer | Inhibition of cell growth | Liang et al. (2017) |
| Melanoma | Protein | + | Regulation of chromosome segregation; tumorigenesis | Obscure | Uzdensky et al. (2014) |
| Neuroblastoma | Gene | + | Stimulates tumor progression; a potential target. | Inhibition of cell growth; mitotic arrest | Balamuth et al. (2010) |
| Synovial sarcoma | + | A novel target for sarcoma diagnosis and prognosis | Obscure | Yao et al. (2021) | |
| Retinoblastoma | Gene | + | A novel biomarker; correlated with the invasive behaviors | Obscure | Shi et al. (2021) |
| Medulloblastoma | + | A potential therapeutic target. | Activation of TP53 or TP73 and cell death signaling pathways | Iegiani et al. (2021) | |
| Breast cancer | Gene | + | Associated with poor prognosis; increased JQ1 sensitivity | Obscure | Kung et al., 2014; Tian et al., 2021 |
| Esophageal cancer | mRNA | + | Associated with poor overall survival of patients with adenocarcinoma; a novel biomarker and target. | Obscure | Zhu et al. (2019) |
| Lung adenocarcinoma | mRNA& Protein | + | Promotes the proliferation of LUAD cells | Inhibition of cell proliferation | Shan et al. (2019) |
| Non-small-cell lung cancer | mRNA | + | Involved in the occurrence and development of NSCLC. | Obscure | Ma et al., 2019; Hao and Qu, 2019 |
| Glioma | mRNA | + | A novel biomarker and potential therapeutic target. | Obscure | Qi et al. (2020) |
| Hepatocellular carcinoma | mRNA&Protein | - | A tumor suppressor; associated with the prognosis of HCC; a potential biomarker or therapeutic target. | Aneuploidy | Liu et al., 2009; He et al., 2020; Liang et al., 2021 |
| Acute lymphoblastic leukemia | mRNA | +/− | A tumor suppressor and oncogene | Obscure | Jiménez-Ávila et al. (2018) |
Note: Lung adenocarcinoma, LUAD; Non-small-cell lung cancer, NSCLC; hepatocellular carcinoma, HCC; +, high expression level; -, low expression level.