Table 1.
Baseline characteristics of patients with CSN metastases from gastroesophageal carcinoma (N = 120)
| Variable | Brain Metastases Patients, No. (%) (n = 100) |
Leptomeningeal Carcinomatosis Patients, No. (%) (n = 20) |
p-value | Statistic Test |
|---|---|---|---|---|
| Age | 0.002 | Wilcoxon Rank Sum | ||
| Mean | 62.2 (10.9) | 53.6 (11.2) | ||
| Median (min, max) | 64.4 (29.2, 87.8) | 52.7 (30.3, 73.6) | ||
| Race | 0.37 | Fisher Exact | ||
| Non-Asian | 93 (93) | 17 (85) | ||
| Asian | 7 (7) | 3 (15) | ||
| Smoking | 0.71 | Fisher Exact | ||
| Never Smokers | 28 (28) | 8 (40) | ||
| Former Smokers | 49 (49) | 9 (45) | ||
| Currently Smokers | 14 (14) | 3 (15) | ||
| Stage at Diagnosis of GEC | 0.30 | Fisher Exact | ||
| I-III | 35 (35) | 4 (20) | ||
| IV | 65 (65) | 16 (80) | ||
| Stage at Diagnosis of CNS metastasis | 0.004 | Fisher Exact | ||
| IV | 72(72) | 20 (100) | ||
| IV with denovo CNS metastasis | 28 (28) | 0 (0) | ||
| Tumor Histology | 0.12 | Fisher Exact | ||
| Adenocarcinoma | 86 (86) | 20 (100) | ||
| Squamous Cell Carcinoma | 14 (14) | 0 (0) | ||
| Treatment Modality | N/A | |||
| Surgery Followed by Radiation | 25 (25) | NA | ||
| Radiation Only (SRS/WBRT) | 63 (63) | 12 (65) * | ||
| SRS | 13 (21) | N/A | ||
| WBRT | 45 (71) | |||
| Unknown | 5 (8) | |||
| Palliative Care Alone/Best supportive care | 12 (12) | 7 (35) | ||
| ECOG (CNS metastasis) | 0.76 | Fisher Exact | ||
| 0–1 | 80 (80) | 17 (85) | ||
| ≥2 | 20 (20) | 3 (15) |
Abbreviations: ECOG – Eastern Cooperative Oncology Group (ECOG) SRS - stereotactic radiosurgery, WBRT – Whole Brain Radiation Therapy, NA not Applicable