TABLE 2.
Compound list for ZRH identified by HPLC-Q-Exactive-MS/MS analysis.
| NO. | Compounds | tR/min | Formula | Ionization mode | m/z | δ/(ppm) | Fragment ions | Classification | |
|---|---|---|---|---|---|---|---|---|---|
| Theoretical | Measured | ||||||||
| 1 | Quinic acid | 1.04 | C7H12O6 | [M-H] - | 191.05501 | 191.05330 | −8.974 | 191.05330, 173.04311, 85.02716 | Organic acids |
| 2 | L(+)-Tartaric acid | 1.10 | C4H6O6 | [M-H]- | 149.00806 | 149.00670 | −9.156 | 149.00670, 103.03772, 87.00642, 74.02245, 72.99093, 59.01182 | Organic acids |
| 3 | citric acid | 1.18 | C6H8O7 | [M-H] - | 191.01862 | 191.01714 | −7.795 | 191.01714, 173.00621, 111.00628 | Organic acids |
| 4 | Monoglyceride citrate | 2.16 | C9H14O9 | [M-H]- | 265.05540 | 265.05438 | −3.880 | 265.05438, 173.00641, 111.00632 | Esters |
| 5 | Gallic acid | 3.17 | C7H6O5 | [M-H]- | 169.01314 | 169.01146 | −9.998 | 169.01146, 125.02191, 127.02626, 97.02721 | Organic acids |
| 6 | Methyll citrate | 3.78 | C7H10O7 | [M-H]- | 205.03427 | 205.03253 | −8.531 | 205.03253, 173.00592, 143.03229, 111.00626, 87.00640 | Esters |
| 7 | Gentisic | 5.22 | C7H6O4 | [M-H]- | 153.01823 | 153.01671 | −9.967 | 153.01671, 108.04317, 91.83106 | Organic acids |
| 8 | 3-Phenylpropionic acid | 6.40 | C9H10O2 | [M-H]- | 149.05970 | 149.05824 | −9.836 | 149.05824 | Organic acids |
| 9 | chlorogenic acid | 10.39 | C16H18O9 | [M-H] - | 353.08670 | 353.08606 | −1.837 | 353.08606, 191.05333 | Organic acids |
| 10 | Shanzhiside | 10.62 | C16H24O11 | [M-H] - | 391.12348 | 391.12128 | −5.645 | 391.12128, 167.06853 | Iridoids |
| 11 | Hydroquinone | 10.82 | C6H6O2 | [M + H]+ | 111.04405 | 111.04504 | 8.861 | 111.04504, 110.06110, 55.05545 | Phenols |
| 12 | 3,4-Dihydroxybenzoic acid | 11.46 | C7H6O4 | [M-H]- | 153.01823 | 153.01669 | −1.545 | 153.01669, 109.02705, 108.04298 | Organic acids |
| 13 | Syringaldehyde | 11.95 | C9H10O4 | [M + H]+ | 183.06518 | 183.06668 | 8.165 | 183.06668, 155.10754, 140.08000, 123.04501, 95.05024 | Aldehydes |
| 14 | Gardoside | 12.12 | C16H22O10 | [M-H] - | 373.11292 | 373.11340 | 1.278 | 373.11340, 167.03247 | Iridoids |
| 15 | 2-Isoprpryl malic acid | 12.14 | C7H12O5 | [M-H]- | 175.06009 | 175.05847 | −9.311 | 175.05847, 115.03752, 113.05829, 85.06358 | Organic acids |
| 16 | mussaenosidic acid | 12.30 | C16H24O10 | [M-H] - | 375.12857 | 375.12521 | −8.966 | 375.12521, 213.07413 | Organic acids |
| 17 | Deacetylasperulosidic acid | 12.32 | C16H22O11 | [M-H] - | 389.10783 | 389.10538 | −6.317 | 389.10538, 165.05289 | Iridoids |
| 18 | Procyanidin B2 | 12.60 | C30H26O12 | [M-H]- | 577.13405 | 577.13843 | 7.585 | 577.13843, 179.05315 | Flavonoids |
| 19 | Caffeic acid | 14.16 | C9H8O4 | [M-H]- | 179.03388 | 179.03238 | −8.407 | 179.03238, 135.04268 | Organic acids |
| 20 | phenylacetaldehyde | 15.52 | C8H8O | [M + H]+ | 121.06479 | 121.06580 | 8.330 | 121.06580, 91.05540, 77.03985, 65.03984 | Aldehydes |
| 21 | Geniposide | 15.55 | C17H24O10 | [M + Na]+ | 411.12726 | 411.12860 | −5.368 | 411.12860 | Iridoids |
| 22 | Vanillic acid | 15.76 | C8H8O4 | [M-H]- | 167.03388 | 167.03226 | −1.625 | 167.03226, 152.00893, 108.01902 | Organic acids |
| 23 | Ethyl gallate | 16.10 | C9H10O5 | [M-H]- | 197.04444 | 197.04298 | −7.460 | 197.04298, 169.01155, 124.01389 | Flavonoids |
| 24 | Agarotetrol | 16.97 | C17H18O6 | [M + H]+ | 319.11761 | 319.11905 | 4.497 | 319.11905, 301.10901, 283.09833, 255.10303, 227.10776, 164,04750 | Chromones |
| 25 | Hydroxysafflor yellow A | 17.19 | C27H32O16 | [M-H]- | 611.16066 | 611.15735 | −5.418 | 611.15735, 353.06302 | Flavonoids |
| 26 | Taxifolin | 17.67 | C15H12O7 | [M-H]- | 303.04992 | 303.04843 | −4.947 | 303.04843, 125.02198 | Flavonoids |
| 27 | Salicylic acid | 18.47 | C7H6O3 | [M-H]- | 137.02332 | 137.02196 | −9.929 | 137.02196, 94.02755, 93.03232, 65.03764 | Organic acids |
| 28 | Methyl cinnamate | 18.51 | C10H10O2 | [M + H]+ | 163.07535 | 163.07629 | 5.727 | 131.05023, 121.10234, 107.05025, 103.05519 | Esters |
| 29 | Isoquercitrin | 18.84 | C21H20O12 | [M-H] - | 463.08710 | 463.08466 | −5.274 | 463.08466, 301.03217, 255.02670 | Flavonoids |
| 30 | safflor yellow A | 19.39 | C27H35O15 | [M-H]- | 598.18922 | 598.18524 | −6.656 | 598.18524 | Flavonoids |
| 31 | Rutin | 19.51 | C27H30O16 | [M-H]- | 609.14501 | 609.14172 | −5.403 | 609.14172, 300.02469, 271.02185 | Flavonoids |
| 32 | quercetin | 19.64 | C15H10O7 | [M + H]+ | 303.04992 | 303.05182 | 6.239 | 303.05182, 229.05084, 257.04620 | Flavonoids |
| 33 | Ellagic acid | 19.97 | C14H6O8 | [M + H]+ | 303.01354 | 303.01547 | 6.357 | 303.01547, 285.00488 | Organic acids |
| 34 | (-)-Epicatechin | 20.61 | C15H14O6 | [M + H]+ | 291.08631 | 291.08801 | 5.824 | 291.08801, 289.07269, 165.05598, 139.04007 | Flavonoids |
| 35 | Coumarin | 20.68 | C9H6O2 | [M + H]+ | 147.04405 | 147.04503 | 6.624 | 147.04503, 119.05021, 103.04573, 95.05064, 91.05537 | Coumarins |
| 36 | Nicotiflorin | 20.69 | C27H30O15 | [M-H] - | 593.15009 | 593.14716 | −4.951 | 593.14716, 325.06290 | Flavonoids |
| 37 | Kaempferol 7-O-glucoside | 20.93 | C21H20O11 | [M-H]- | 447.09218 | 447.09146 | −1.628 | 447.09146, 284.03000 | Flavonoids |
| 38 | Methylellagic acid | 21.79 | C15H8O8 | [M-H]- | 315.01354 | 315.01199 | −4.932 | 315.01199, 300.99188 | Organic acids |
| 39 | Naringetol | 23.73 | C15H12O5 | [M-H]- | 271.06009 | 271.05881 | −1.290 | 271.05881, 151.00104, 120.05093, 119.04774, 107.01142 | Flavonoids |
| 40 | D(+)-Camphor | 24.88 | C10H16O | [M + H]+ | 153.12739 | 153.12837 | 6.389 | 153.12837, 108.08988, 95.08677, 81.07110, 69.07112, 55.01922 | Ketones |
| 41 | 6-Hydroxy-2-(2-phenylethyl)chromone | 25.25 | C17H14O3 | [M + H]+ | 267.10157 | 267.10294 | 5.126 | 267.10294, 176.04791, 161.13408, 137.09688 | Chromones |
| 42 | apigenin | 25.43 | C15H10O5 | [M-H]- | 269.04444 | 269.04306 | −5.166 | 269.04306 | Flavonoids |
| 43 | dehydrocholic acid | 25.54 | C24H34O5 | [M-H]- | 401.23225 | 401.23148 | −1.921 | 401.23148 | Organic acids |
| 44 | Kaempferol | 25.57 | C15H10O6 | [M-H]- | 285.03936 | 285.03790 | −5.138 | 285.03790 | Flavonoids |
| 45 | 5,8-dihydroxy-2-(2-phenylethyl)chromone | 25.69 | C17H14O4 | [M + H]+ | 283.09648 | 283.09808 | 5.633 | 283.09808, 192.04300 | Chromones |
| 46 | Myrcene | 26.98 | C10H16 | [M + H]+ | 137.13247 | 137.13342 | 6.876 | 137.13342, 93.07101, 69.07106, 79.05540 | Alkenes |
| 47 | stearic acid | 28.96 | C18H36O2 | [M-H]- | 283.26315 | 283.26245 | −2.495 | 283.26245 | Organic acids |
| 48 | Glycocholic acid | 29.18 | C26H43NO6 | [M-H]- | 464.30066 | 464.29800 | −5.739 | 464.29800, 74.02259 | Organic acids |
| 49 | 6-methoxy-2-(2-phenylethyl)chromen-4-one | 29.23 | C18H16O3 | [M + H]+ | 281.11722 | 281.11865 | 5.084 | 281.11865, 190.06349, 151.03923 | Chromones |
| 50 | Deoxycholic acid | 30.63 | C24H40O4 | [M-H]- | 391.28428 | 391.28229 | −5.102 | 391.28229 | Organic acids |
| 51 | Hyocholic acid | 30.85 | C24H40O5 | [M-H]- | 407.27920 | 407.27710 | −5.158 | 407.27710 | Organic acids |
| 52 | 2,6-Dimethoxyphenol | 31.21 | C8H10O3 | [M + H]+ | 155.07027 | 155.07137 | 7.089 | 155.07137, 154.96363, 139.04002, 111.04516, 96.05373, 93.03458 | Phenols |
| 53 | 2-(2-phenylethyl)chromon | 31.70 | C17H14O2 | [M + H]+ | 251.10665 | 251.10797 | 5.232 | 251.10797, 173.13361, 161.13316, 121.08686 | Chromones |
| 54 | γ-Linolenic acid | 32.43 | C18H30O2 | [M + H]+ | 279.23185 | 279.23428 | 8.678 | 279.23428, 262.22650, 261.22302, 243.21196, 195.13866 | Fatty acids |
| 55 | Chenodeoxycholic acid | 32.78 | C24H40O4 | [M-H]- | 391.28428 | 391.28214 | −5.485 | 391.28214 | Organic acids |
| 56 | beta-elemene | 33.01 | C15H24 | [M + H]+ | 205.19507 | 205.19635 | 6.202 | 205.19635, 81.07110, 67.05546, 55.05541 | Alkenes |
| 57 | Elaidic acid | 35.24 | C18H34O2 | [M + H]+ | 283.26315 | 283.26498 | 6.436 | 283.26498, 109.10230, 95.08684, 81.07112, 69.07116, 57.07118 | Fatty acids |
| 58 | Oleanolic acid | 35.91 | C30H48O3 | [M-H]- | 455.35197 | 455.34949 | −5.450 | 455.34949 | Triterpenoids |
| 59 | palmitic acid | 37.63 | C16H32O2 | [M-H]- | 255.23185 | 255.23038 | −5.786 | 255.23038 | Fatty acids |
| 60 | Icosanoic acid | 38.43 | C20H40O2 | [M-H]- | 311.29445 | 311.29291 | −4.969 | 311.29291, 119.14525 | Organic acids |