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. 2024 Mar 28;14:7400. doi: 10.1038/s41598-024-57570-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Time course for the mutations measured by DNA-DeepNGS and RNA-NestedNGS, and BCR::ABL1 levels present in the most clinically relevant patients. Y-axis represents the value of RNA-NestedNGS VAF corrected by the ratio BCR::ABL1 (green), DNA-DeepNGS VAF (blue) or ratio BCR::ABL1/ABL1 (red). ALL acute lymphoblastic leukemia, Asci asciminib, B bosutinib, CML chronic myeloid leukemia, D dasatinib, I imatinib, N nilotinib, Niv nivolumab, P ponatinib, R relapse, VAF variant allele frequency.