Table 2.
Comparison of CAR- and TCR-engineered NK cells
CAR | TCR | |
---|---|---|
HLA restricted | No | Yes |
Antigen density required | High | Low |
Intracellular targeting | No | Yes |
Multiplexing | Yes | Yes |
Off the shelf | Yes | Yes |
Clinical test | Yes | No |
Comparison of CAR- and TCR-engineered NK cells
CAR | TCR | |
---|---|---|
HLA restricted | No | Yes |
Antigen density required | High | Low |
Intracellular targeting | No | Yes |
Multiplexing | Yes | Yes |
Off the shelf | Yes | Yes |
Clinical test | Yes | No |