TABLE 2.
Presence of the PTXRS subdomain in viral proteinsa
| Viral protein | Amino acid sequence |
|---|---|
| AMV and ilarvirus RNA binding consensus |  |
| SFV nsP4 | |
| VEE nsP4 | |
| ONN nsP4 | |
| Parvovirus VP-1 | |
| TYMV polyprotein | |
| HCV core | |
PTXRS, a subdomain of the AMV and ilarvirus RNA binding consensus sequence (4), is found in a number of virus proteins that have RNA binding potential. Amino acids comprising the RNA binding consensus are enclosed in boxes; multiple amino acids in a single box reflect conservative substitutions among the AMV and ilarvirus coat proteins (4). The PTXRS subdomain is surrounded by a dotted line; X, any amino acid. The crucial arginine that is required for RNA binding (4) is indicated by the arrow. Abbreviations: SFV, Semliki Forest virus; VEE, Venezualan equine encephalitis virus; ONN, o’nyong-nyong virus; nsP4, nonstructural protein 4, the putative polymerase; VP-1, coat protein; TYMV, turnip yellow mosaic virus; HCV, hepatitis C virus. Homology with the AMV and ilarvirus consensus sequence is indicated by uppercase letters.