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. 2024 Mar 18;10(7):e27837. doi: 10.1016/j.heliyon.2024.e27837

Table 1.

Demographics and clinicopathologic characteristics of invasive triple-negative breast cancer patients in SEER database.

Variables All patients, (n = 46,902) 2010–2016
With Liver metastasis (Training) (n = 515)
2017–2018
With Liver metastasis (validation) (n = 100)
Without Liver metastasis (n = 46,287)
Age, median (IQR) 59 (49, 69) 59 (49.5, 69) 62 (51,70) 59 (49,69)
Race, n (%)
 White 33674 (71.8) 367 (71.2) 69 (69.0) 33238 (71.8)
 Black 9613 (20.5) 123 (23.9) 29 (29.0) 9461 (20.4)
 Asian&Pacific Islander 3349 (7.1) 22 (4.3) 2 (2.0) 3325 (7.2)
 American Indian&Alaska Nativ 266 (0.6) 3 (0.6) 0 (0) 263 (0.6)
T stage, n (%)
 I 21179 (45.2) 60 (11.7) 9 (9) 21110 (45.6)
 II 19118 (40.8) 156 (30.3) 32 (32.0) 18930 (40.9)
 III 3766 (8.0) 97 (18.8) 21 (21.0) 3648 (7.9)
 IV 2839 (6.0) 202 (39.2) 38 (38.0) 2599 (5.6)
Nodal status, n (%)
 N0/N1 42134 (89.8) 352 (68.3) 61 (61.0) 41721 (90.1)
 N2/N3 4768 (10.2) 163 (31.7) 39 (39.0) 4566 (9.9)
Marital, n (%)
 Single 20734 (44.2) 284 (55.2) 59 (59.0) 20391 (44.1)
 Married 26168 (55.8) 231 (44.8) 41 (41.0) 25896 (55.9)
Grade, n (%)
 I 884 (1.9) 4 (0.8) 1 (1.0) 879 (1.9)
 II 8344 (17.8) 92 (17.8) 12 (12.0) 8240 (17.8)
 III 37419 (79.8) 414 (80.4) 87 (87.0) 36918 (79.8)
 IV 255 (0.5) 5 (1.0) 0 (0.0) 250 (0.5)
Laterality, n (%)
 Left 24095 (51.37) 268 (52.0) 49 (49.0) 23778 (51.37)
 Right 22797 (48.61) 244 (47.4) 50 (50.0) 22503 (48.62)
 Bilateral 10 (0.02) 3 (0.6) 1 (1.0) 6 (0.01)
Histologic Type, n (%)
 IDC 43005 (91.7) 475 (92.2) 91 (91.0) 42439 (91.7)
 ILC 633 (1.3) 12 (2.3) 0 (0.0) 621 (1.3)
 Other 3264 (7.0) 28 (5.5) 9 (9.0) 3227 (7.0)
With Brain Metastasis, n (%)
 No 46689 (99.5) 457 (88.7) 92 (92.0) 46140 (99.7)
 Yes 213 (0.5) 58 (11.3) 8 (8.0) 147 (0.3)
With Lung Metastasis, n (%)
 No 46051 (98.2) 319 (61.9) 64 (64.0) 45668 (98.7)
 Yes 851 (1.8) 196 (38.1) 36 (36.0) 619 (1.3)
With Bone Metastasis, n (%)
 No 45949 (98.0) 268 (52.0) 43 (43) 45638 (98.6)
 Yes 953 (2.0) 247 (48.0) 57 (57) 649 (1.4)
Surgery, n (%)
 No 3211 (6.9) 324 (62.9) 69 (69.0) 2818 (6.1)
 Yes 43691 (93.1) 191 (37.1) 31 (31.0) 43469 (93.9)
Radition, n (%)
 No/unkown 24237 (51.7) 385 (74.8) 74 (74.0) 23778 (51.4)
 Yes 22665 (48.3) 130 (25.2) 26 (26) 22509 (48.6)
Chemotherapy, n (%)
 No/unkown 12198 (26.0) 121 (23.5) 22 (22.0) 12055 (26.0)
 Yes 34704 (74.0) 394 (76.5) 78 (78.0) 34232 (74.0)

SEER: Surveillance, Epidemiology, and End Results; IDC: invasive ductal carcinoma; ILC: invasive lobular carcinoma; IQR: interquartile range.