Table II.

Summary of recommended steps in PEP management of HCWs exposed to HBV

Vaccination & anti-body status	Treatment of source is:		Treatment if the source patient is unknown or unavailable for testing
	HBsAg +VE	HBsAg-VE
1. Unvaccinated/partially vaccinated	HBIGa1 & initiate/complete vaccine seriesb	Initiate/complete. vaccination series	Initiate/complete vaccination series
2. Completely vaccinated & responder	No treatment required	No treatment required	No treatment required
3. Completely vaccinated and nonresponder 4. True nonresponder (6 doses of HBV vaccine)	1 dose of HBIG & initiate 2nd vaccination series 2 doses of HBIG given one month apart	No treatment is needed. No Treatment is needed.	Treat as if the source were HBsAg +VE Treat as if the source were HBsAg +VE
5. Antibody response is unknown	Test for antibodies. If adequate, no treatment is needed. If inadequate, HBIGa1 and a vaccine booster are required	No Treatment Required	If Anti-HBs are adequate, no treatment is needed. If inadequate, HBIGa1 and a vaccine booster are required Recheck titre I 1–2 months

Adapted from Beekmann & Henderson, 2015; CDC, 2001.

^aHepatitis B immunoglobulin.

^bGiven at different sites.